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ISO 19290:2021

ISO 19290:2021

Cigarettes — Determination of tobacco specific nitrosamines in mainstream cigarette smoke — Method using LC-MS/MS

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General Information

Status : Active

Standard Type : Main

Document No : ISO 19290:2021

Document Year : 2021

Pages : 14

Edition : 2

Section Volume : Tobacco and tobacco products (ISO/TC 126.)

ICS : Tobacco, tobacco products and related equipment (65.160)

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

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